名称：4-吗啉哌啶三氟乙酸盐
英文名称：4-(Piperidin-4-yl)morpholine 2,2,2-trifluoroacetate
分子式：C9H18N2O
分子量: 170.25
Cas No.：:436099-97-7
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
dichloromethane;
Reactants can be synthesized in 1 step.
WYETH, WO2007/92435, A2, (2007) Step 22B; 4-morpholin-4-yl-piperidine-l-carboxylic acid tert-butyl ester (3.85g, 14.2) was dissolved in 25 mL dichloromethane and 2OmL trifluoroacetic acid was added and stirred at room temperature fo r 90 minutes. The reaction mixture was then evaporated then co-evaporated twice with dichloromethane. The semisolid residue was triturated with 75mL ether, stirred at room temperature 1 hour, then fil tered to give 5.03g of 4-piiperidin-4-yl-morpholine, bis- trifluoroacetic acid salt (89percent) as a white solid.
