中文名称：2-(4-氨基苯基)乙基]丙二酸叔丁酯
英文名称：2-(4-AMINO-PHENYL)-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER
分子式：C13H20N2O2
分子量: 236.31
Cas No.：:94838-59-2
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
Reactants are commercially availlable.
BioChem Pharma Inc., US6274620, B1, (2001) [2-(4-Amino-phenyl)-ethyl]-carbamic acid tert-butyl ester (Y-1). To a mixture of 2-(4-Amino-phenyl)-ethylamine (300 mg, 2.2 mmol), ditertbutoxyanhydride (480 mg, 2.20 mmol), DMAP (54 mg, 0.44 mmol) DI EA (0.372 ml, 2.3 mmol) in DMF (80 mL), was stirred overnight at room temperature. Insoluble particles were removed by filtration and the solvent was evaporated. Purification of the residue on silica gel (1:3 hexane:EtOAc) gave 270 mg (52percent) of pure [2-(4-Amino-phenyl)-ethyl]-carbamic acid tert-butyl ester. 1H-NMR (300 MHz, CDCl3) delta: 1.36 (s, 9H), 2.81 (t, 2H), 3.40 (m, 2H), 3.64 (bs, 1H ), 4.63(bs, 1H), 6.72(d, 2H), 7.03 (d, 2H).
