Product name：2-Bromo-4-thiazolecarboxylic acid
MF：C4H2BrNO2S
Cas No.：5198-88-9
MW：208.03
Structure：
Purity：95%
Appearance：yellow solid
Product use：Basic raw materials, organic intermediates, pharmaceutical intermediates
The synthesis process is as follows:
lithium hydroxide; tetrahydrofuran;
Reactants are commercially availlable.
IGNAR, DIANE MICHELE, US2010/113512, A1, (2010) Step 1: 2-Bromo-1,3-thiazole-4-carboxylic Acid A mixture of methyl 2-bromo-1,3-thiazole-4-carboxylat e (4.2 g, 18.9 mmol), THF (120 mL) and 1N lithium hydroxide (50 mL) was heated at 70°C. for 1 h. Th e organic solvent was removed in vacuo. The residual aqueous solution was cooled to 0-5°C. and acid ified to pH1 with 1N HCl solution. The tile compound was obtained by filtration, as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 8.43 (s, 1H) 13.30 (s, 1H).
