诺利斯医药正在热销：
别名：2-溴噻唑-4-甲醇
英文名称：2-Bromo-4-fomylthiazole
分子式：C4H4BrNOS
Cas No.：5198-86-7
分子量：194.05
结构式：
规格：95%
外观：棕色液体
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
sodium tetrahydroborate; water; lithium chloride; tetrahydrofuran;
Reactants are commercially availlable.
PETERSON,Michael, T., WO2015/57585, A1, (2015) Preparation of (2-bromothiazol-4-yl)methanol (5)To a solution of ester 4 (10.0 g, 42.4 mmol, 1 equiv) in THF (200 mL) was added NaBH4 (4.81 g, 127 mmol, 3 equiv), LiCl (5.4 g, 130 mmol, 3 equiv) and H2O (40 mL). The resulting biphasic mixtu re was vigorously stirred for 2 h, after which TLC (20percent EtOAc:hexanes) showed complete consumption of starting material. The reaction was quenched with saturated aqueous NH4Cl (200 mL), diluted with EtOAc (200 mL), and the layers were separated. The aqueous layer was extracted with EtOAc (100 mL), and the organic layers were combined, dried (Na2SO4), filtered, and concentrated under reduced pressure to give the title compound as a yellow semi-solid (7.82 g, 95percent). Rf= 0.2 (SiO2, 20percent EtOAcrhexanes); 1H and 13C NMR of the product matched those previously reported (Wipf and Wang 2007).
