别名：叔丁基-2,6-二甲基-4-氧代哌啶-1-甲酸叔丁酯
英文名称：tert-butyl 2,6-dimethyl-4-oxopiperidine -1-carboxylate
分子式：C12H21NO3
Cas No.：604010-24-4
分子量：227.31
结构式
规格：95%
外观：浅黄色固体
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
triethylamine; dichloromethane;
Reactants can be synthesized in 1 step.
KESICKI, Edward A., WO2015/103060, A1, (2015) [0359] Preparation of tert-butyl 2,6-dimethyl-4-oxopiperidine-l-carboxylate (9.37): To an ice-cold solution of 2,6-dimethylpiperidin-4-one 9.36 (3.6 g, 28.34 mmol) in DCM (50 mL) was added Et3N (9.8 m L, 70.8 mmol) and boc anhydride (12.1 mL, 56.6 mmol). The resulting reaction mixture was stirred at RT for 16 h. After completion of the reaction (TLC monitoring), the reaction mass was diluted with w ater and extracted with DCM (3 times). The combined organics was washed with brine, dried over anhydrous Na2S04, filtered and concentrated. The crude was purified over silica gel (100-200 M, 10-15perc ent) EtOAc-hexane) to get the desired product 9.37 (3.9 g, Yield: 60.9percent). [0360] 1H-NMR (400 MHz, CDC13): delta 2.85 (d, J=6.4 Hz, 1H), 2.81 (d, J=6.4 Hz, 1H), 2.38-2.39 (m, 2H), 2.34-2.36 (m, 2 H), 1.48 (s, 9H) and 1.25-1.27 (m, 6H). MS: 228.08 (M+H)+.
