别名：3,3-二氟吡咯烷盐酸
英文名称：3,3-Difluoropyrrolidinehydrochloride
分子式：C4H8ClF2N
Cas No.：163457-23-6
分子量：143.56
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
hydrogenchloride; 1,4-dioxane;
Reactants are commercially availlable.
Stein, Philip D., US2004/186134, A1, (2004) [0358] Part C: To a solution of 1,1-dimethylethyl 3,3-difluoropyrrolidine-1-carboxylate (0.868 g, 4.19 mmol) in 1.5 mL of 1,4-dioxane was added a solution of hydrogen chloride in 1,4-dioxane (4 M, 11 mL, 44 mmol) at 0°C. The mixture was stirred at 0°C. for 40 min, at room temperature for 1 h a nd was then concentrated to afford 0.65 g (100percent) of 3,3-difluoropyrrolidine hydrochloride: 1H- NMR (CD3OD) delta 3.54 (2H, t, J=11.9 Hz), 3.43 (2H, t, J=7.8 Hz), 2.40 (2H, m).
