名称:4-氯甲基-2-甲基噻唑盐酸盐
英文名称:4-CHLOROMETHYL-2-METHYLTHIAZOLE HYDROCHLORIDE
分子式:C5H7Cl2NS
分子量: 184.09
Cas No.:77470-53-2
结构式:
规格:95%
用途:基础原料、有机中间体、医药中间体
合成工艺如下:
toluene;
Reactants are commercially availlable.
Dong, Steven, US2003/134883, A1, (2003) EXAMPLE 16 2-methyl-4-(chloromethyl)thiazole A mixture of thioacetamide (6.9 g) and 1,3-dichloroacetone (13.4 g) in 100 mL of toluene is heated under reflux for 2 hours, then cooled to ambient temperature and washed sequentially with sat. N aHCO3 and brine. The solution is dried over MgSO4, filtered, and evaporated. The product is purified by silica gel chromatography.