中文名称：4-溴-3-羟基苯甲酸
英文名称：4-Bromo-3-hydroxybenzoic acid
分子式：C7H5BrO3
Cas No.：14348-38-0
分子量：217.02
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
bromine; acetic acid; ethanol;
Reactants are commercially availlable.
ABBOTT LABORATORIES, WO2005/23762, A1, (2005) Example 56 (2S)-1-{(5R)-5-((5-carboxy-2-bromophenoxy)-methyl)-L-prolyl}-pyrrolidine-2- carbonitrile Example 56A 4-Bromo-3-hydroxy-benzoic acid Bromine (0.37 mL, 7.2 mmol) was added to 3-hydroxy-benzoi c acid (500 mg, 3.6 mmol) in ethanol (2 ML) and acetic acid (1 mL). The mixture was stirred at room temperature for 30 min and then concentrated and purified by column chromatography to give the produ ct (314 mg, 40 percent). MS (DCI) m/z 234 (M+NH4) +.
