英文名称：4-Chloro-5,8-difluoro-2-methyl-quinoline
分子式：C10H6ClF2N
Cas No.：288151-28-0
分子量：213.61
结构式：
规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
trichlorophosphate;
Reactants are commercially availlable.
SmithKline Beecham p.l.c., US6699879, B1, (2004) 4-Hydroxy-5,8-difluoro-2-methylquinoline (5.4 g) in phosphoryl chloride (60 ml) was boiled for 4 h. The mixture was cooled to room temperature, excess phosphoryl chloride removed at reduced pressure, the residue dissolved in ethyl acetate, washed with sodium hydrogen carbonate, dried (Na2SO4) and solvent removed at reduced pressure. The title compound (5.35 g) was isolated as a brown powder. (Meth od B). 1H NMR delta: 2.61 (3H, s), 7.46 (1H, m), 7.66 (1H, m), 7.81 (1H, s).
